Bayesian estimation of basal conditions on Rutford Ice Stream, West Antarctica, from surface data

first_imgThe determination of basal properties on ice streams from surface data is formulated as a Bayesian statistical inference problem. The theory is applied to a flowline on Rutford Ice Stream, West Antarctica. Estimates of bed topography and basal slipperiness are updated using measurements of surface topography and the horizontal and vertical components of the surface velocity. The surfacetopography is allowed to vary within measurement errors. We calculate the transient evolution of the surface until rates of surface elevation change are within limits given by measurements. For our final estimation of basal properties, modelled rates of elevation change are in full agreement with estimates of surface elevation changes. Results are discarded from a section of the flowline where the distribution of surface residuals is not consistent with error estimates. Apart from a general increasein basal slipperiness toward the grounding line, we find no evidence for any spatial variations in basal slipperiness. In particular, we find that short-scale variability (<10× ice thickness) in surface topography and surface velocities can be reproduced by the model by variations in basal topography only. Assuming steady-state conditions, an almost perfect agreement is found between modelled and measured surface geometry, suggesting that Rutford Ice Stream is currently close to a steady state.last_img read more

Seeding startups

first_imgOne Harvard research team has shown how an immense amount of data can be stored in custom-built strands of DNA. Where does that technology’s greatest value lie? Another lab has a 3-D printer knitting cells into blocks of living tissue with embedded, functional vasculature. Should these be deployed as models of disease, for drug discovery, or as the future of wound healing?Each case requires an experienced leader’s systematic approach to turn a stunning innovation into a transformative business plan.For advanced technologies across the University, a new entrepreneur-in-residence (EIR) program launched by Harvard Office of Technology Development (OTD) might offer a crucial bridge to commercial development.“We want to see as many startups come from Harvard as possible,” said Isaac T. Kohlberg, senior associate provost and chief technology development officer. “In order to launch startups, you need initial CEOs and executives, and you need to identify them early on to work with the researchers and scientists.”The first EIRs in the program, in 2017, included Shahid Azim, a serial entrepreneur who focuses on bioelectronics and non-invasive sensing, and Nat Harrison, a Chicago-based entrepreneur with a background in materials science, chemistry, and optoelectronics. Their time on campus sparked discussions beyond their expectations and nurtured business development efforts that still continue.With at least two more EIRs on board for 2018, and further recruitment underway, OTD’s program is poised to deliver a new set of perspectives — and perhaps a sense of urgency — to faculty, postdocs, and graduate students who feel a tug toward the startup life.“Even for the kind of businesses that come out of universities, the proprietary tech is only one piece of it,” said Harrison, who relocated to Boston to participate. “There’s always more value that’s built in either the business system or the enterprise that’s launched.“I often see a tendency among researchers to say, ‘Let’s wait, let’s get our ducks in a row and do another paper. Let’s not tell people about our technology yet.’ There’s kind of a stealth bias, and I think that’s the wrong bias,” Harrison said. “I think you need to have a speed bias. The speed bias says, talk to more people and figure out if there’s a ‘there’ there — if they want it, if you can do it.”Shahid Azim (from left) and Nat Harrison, entrepreneurs in residence at Harvard, shared their advice and perspectives in a discussion moderated by Sam Liss, executive director of strategic partnerships in OTD. Photo by Caroline Perry/OTDBridging lab to businessWhile related programs exist at Harvard Business School, Harvard Innovation Labs, and Harvard’s Wyss Institute, bringing EIRs into the Cambridge and Longwood labs for extended periods represents a new mechanism for focused technology development efforts at the University.“Commercially speaking, when you talk about transferring research from the academic to the real world, the transfer is rarely successful without having talented, dedicated individuals to play a major role in that trajectory,” said Kohlberg.Bruce Bean, the Robert Winthrop Professor of Neurobiology at Harvard Medical School (HMS), knows the difference an entrepreneurial adviser can make. His lab co-developed a technology that could one day treat chronic cough and other ailments, and a startup is in the works.“As scientists, we can take the work up to a certain point, but most of us have little or no experience in what it takes to go from promising effects in animals to [human] clinical studies, and particularly to know what investors are going to look for and what their concerns are,” Bean said. “A seasoned entrepreneur has the expertise to go from the science to figuring out whether it’s going to be commercially viable.”Since 2005, when Kohlberg arrived at Harvard to lead OTD, this unit of the provost’s office has helped to launch more than 100 companies built around Harvard technologies. The staff is focused on providing a series of bridges from the lab to the startup, whether in the form of research funding, advice and networking, or strategic planning.Much of OTD’s success has come from the life sciences, where commercially promising research can get an extra boost from the Blavatnik Biomedical Accelerator, and where emerging companies benefit from Boston’s robust early-stage venture ecosystem. Heavy hitters have included Genocea Biosciences (vaccines), Selecta Biosciences (biologic therapies), Editas Medicine (genome editing), Tetraphase Pharmaceuticals (antibiotics), and Magenta Therapeutics (stem cell transplantation). Outside of the life sciences, Harvard’s pilot Physical Sciences & Engineering Accelerator has demonstrated early success with startups like Voxel8 (3-D printing), Perusall (educational technology), and RightHand Robotics (warehouse automation).“Harvard is producing a lot of high-quality stuff that’s got commercial legs,” said Harrison, who spent much of his time on campus last year connecting with researchers at the intersection of materials science, computer science, and biology. “The smaller departments are punching above their weight.”Essential inputThe EIR program promises to provide greater entrepreneurial and strategic leadership to translational research projects University-wide. Kohlberg plans to bring in between five and eight EIRs with expertise to inform all areas of life science and physical science and, over time, rotate in new candidates. The point, he said, is that in the right hands — with companies that are committed and well equipped — potent innovations can be developed to their fullest potential.To maximize the potential for serendipity, the program is flexible. According to Kohlberg, an EIR can work horizontally across a number of projects, groups, and individuals, scanning the fertile research environment for opportunities. Or, an EIR can engage vertically, identifying a specific project and working with the research group to turn the concept into a startup.In either case, EIRs can make connections to prospective investors and provide advice, mentorship, and coaching about the startup process. They can offer counsel on business models and on fundraising strategies, as well as on how to pitch an idea and address the business challenges unique to each innovation.“The EIRs will talk to all these various faculty, postdocs, and graduate students. We’ll introduce them to people, and they’ll find a bunch on their own,” said Sam Liss, executive director for strategic partnerships in OTD. “Being an EIR gives them a platform from which to go find interesting technology and see what develops out of it.”For Azim, who previously helped launch three venture-backed startups, inspiration came easily: “I was just blown away by people’s curiosity to solve problems, and their creativity, frankly.” He said it was rewarding to be able to contribute an external perspective. “As they are deep into very specialized research, most of these students and researchers don’t have the professional network at this stage to tap into industry thought leadership or key decision-makers. The EIR program is a really good mechanism to bridge that chasm.”Harrison and Azim each have met and mentored many research teams at the University.,Azim said it was like being “a kid in a candy store.”“A lot of these building blocks in the lab, very early-stage, are really pushing the boundaries,” he said. “You start to see a pattern emerge where eventually dots converge from various pieces that would eventually deliver a really, really large impact, whether it’s in healthcare, transportation, or any number of industries.”“I was privy to see some data that was still in the lab, especially from the Lewis Group,” the lab where living tissues are printed from bio-inks, “and it was just amazing to see what is even possible. It’s easy to see where this work can have a huge impact.”That experience, of both intellectual stimulation and practical contribution, is now open to Gus Simiao, who joined the EIR program in January. Simiao is a principal at venture investment group CEVG. He specializes in startups in the areas of sensors, robotics, machine learning, energy, and mobility.Raffaella Squilloni, M.B.A. ’10, is also newly on board, with a plan to focus mainly on the commercial development of a new vaccine platform. As an HBS Blavatnik fellow last year, Squilloni connected with researchers at HMS who are advancing a live attenuated vaccine for Zika, Dengue, and West Nile Virus, as well as a novel self-adjuvanting mRNA vaccine platform that can be applied to some infectious diseases or even cancer. As an EIR, she will work with the research team to define a business plan.The vaccine project has entered the “final stage of incubation in which both the technology and the business proposition are readied for the launch of a new company,” said Michal Preminger, executive director of OTD’s HMS office. Squilloni is poised to take the leadership role in the startup, Arbothera, when her time as EIR concludes, as “someone who will live and breathe and focus 100 percent of her energy on getting this company off the ground.”Gus Simiao and Raffaella Squilloni, M.B.A. ’10, joined OTD’s EIR program in January. Courtesy of OTDFinding the right fitMany of OTD’s directors of business development launched companies of their own in earlier careers, yet the level of focus and expertise the EIRs can bring complements that experience and “expands the ways we can be helpful,” Liss said. “It facilitates researchers’ access to someone who has good access to the capital markets, can raise money, and has demonstrable experience taking an early-stage technology and translating that into a real startup. It’s a unique role.”The ideal EIR, he said, can prompt an “intellectually honest discussion about whether the technology is really appropriate to be the platform for launching a startup or not.” Does it truly solve a problem? What might the product be? How is that validated? What is the big picture?OTD’s program opens a potent opportunity for talented entrepreneurs “to work with some of our most visionary faculty at the earliest stages of startup formation,” Kohlberg said. It offers an invitation to browse, to forge new connections — and perhaps to catch lightning in a bottle.“These university spinouts very often work best where there’s someone in the research group, a postdoc or a Ph.D., who comes with the business when they’ve finished their work or their education on campus,” said Harrison. “The success scenario is a match between an entrepreneur and a researcher.” That success, he added, depends on being in the right place at the right time.“The opportunities are there, and the doors are not that hard to open for those who are interested,” Harrison added. “Normally you would expect that you’re looking for the needle in the haystack. Here, I would say there are plenty of needles.”Are you interested in becoming an entrepreneur-in-residence? Please contact OTD.last_img read more

Wolf Administration Opens Public Inquiry Hotline to Coordinate Volunteers for Flood Clean-Up

first_img Press Release,  Public Health,  Public Safety,  Weather Safety Harrisburg, PA – Governor Tom Wolf today said a public inquiry hotline is now available to citizens who need assistance cleaning up after devastating flooding in central and eastern Pennsylvania.“We’re working with volunteer organizations that have offered to help residents in these communities,” said Governor Wolf. “I know that some of these survivors have been hit multiple times in the last few weeks, and the willingness of these volunteers to do this hard work is greatly appreciated.”Anyone who would like to request help should call 272-200-3211 for assistance. The hotline will be staffed from 8 a.m. to 8 p.m., including weekends through August 31. Volunteers will provide physical labor, such as mucking out basements, removing damaged flooring and drywall, and removing debris.A variety of organizations make up the PA VOAD (Voluntary Organizations Active in Disasters).They provide assistance that complements the efforts of municipal, county and state governments. Their members active in this recovery mission include the American Red Cross, Southern Baptist Convention, United Methodist Committee on Relief (UMCOR), Lions Club International, Salvation Army, Team Rubicon, A.G.A.P.E of Columbia County, Mennonite Disaster Services, United Church of Christ, LDS Charities, Lend-a-Hand of Lebanon County, and Lutheran Disaster Response.Callers will need to provide basic information, including but not limited to their address, the type of work they need help with, and the status of utility services at the site. Callers will also need to verbally give their permission for call takers to share their information with the volunteer organizations.PEMA Director Rick Flinn said that while every effort will be made to help those who need it, the responding organizations will prioritize service delivery according to their own criteria and ability to assist. It may take several days for volunteer teams to respond.In addition, the Disaster Distress Helpline, 1-800-985-5990, is a 24/7 national hotline dedicated to providing immediate crisis counseling for people who are experiencing emotional distress related to any natural or human-caused disaster. This toll-free, multilingual, and confidential crisis support service is available to all residents in the United States and its territories. Stress, anxiety, and other depression-like symptoms are common reactions after a disaster. Call 1-800-985-5990 or text TalkWithUs to 66746 to connect with a trained crisis counselor.“We know that this has been a stressful time for flooding survivors as well as first responders who have been doing stressful and dangerous work to help their neighbors,” Flinn said. “Please reach out if you need someone to talk to. Free help is available 24 hours a day, seven days a week.” Wolf Administration Opens Public Inquiry Hotline to Coordinate Volunteers for Flood Clean-Up August 17, 2018center_img SHARE Email Facebook Twitterlast_img read more

EPL: Calvert-Lewin brace hands Everton win at Newcastle

first_imgEverton striker Dominic Calvert-Lewin kept up his fine run of form as he scored twice to give Everton a 2-1 win at Newcastle United in a pulsating Premier League clash on Saturday.Advertisement Loading… The 22-year old fired the visitors ahead in the 13th minute, sweeping the ball home from six metres after a deflected Gylfi Sigurdsson shot fell kindly for him.Chances went begging at either end before Fabian Schar volleyed in a 59th-minute equaliser, firing past Jordan Pickford after Andy Carroll had headed a Jetro Willems free kick into the defender’s path.Read Also: Ancelotti ready to block Man Utd £70m transfer bid for Everton strikerEverton, whose lightning breaks kept carving open the home team’s defence all afternoon, struck again five minutes later when Calvert-Lewin bundled in Richarlison’s perfect low cross from the right.Newcastle threw men forward in the closing stages but Everton held on to extend their unbeaten league run to five games, while the Magpies suffered their first home defeat in nine outings.FacebookTwitterWhatsAppEmail分享 center_img It was a second successive victory for Everton’s new manager Carlo Ancelotti, who made his debut at Goodison Park with a 1-0 win over Burnley on Thursday when Calvert-Lewin netted a late winner for the Toffees.last_img read more

The Latest: Swiss soccer to restart earlier to help Basel

first_img Share This StoryFacebookTwitteremailPrintLinkedinRedditThe Latest on the effects of the coronavirus outbreak on sports around the world:___The Swiss soccer league will restart several days earlier than planned to help Europa League contender Basel cope with a backlog of matches in August. ___More AP sports: and June 4, 2020 Associated Press center_img The restart amid the coronavirus pandemic was set for June 19-21 in the top two divisions.The Swiss soccer federation now says Basel’s Swiss Cup quarterfinal match against Lausanne Sport will be played without fans on June 14 instead of the Aug. 5-6 dates for the other quarterfinal matches.Basel is scheduled to resume play in the Europa League in early August. It holds a 3-0 lead over Eintracht Frankfurt from the first leg of the round of 16.Basel also faces a potential clash with this season’s Europa League possibly overlapping with next season’s preliminary rounds.Basel is currently in third place in the Swiss league and the third-place team should enter the Europa League qualifying rounds in late July or early August. The Latest: Swiss soccer to restart earlier to help Basellast_img read more

Mourinho takes first trophy with Manchester Utd

first_imgTonight in the Premier League Leicester City play their first game since the sacking of Claudio Ranieri when they welcome Liverpool to the King Power Stadium.Kick off is at 8pm. The goals came from Delle Ali and hat-trick for Harry Kane. United enjoyed the perfect start when Zlatan Ibrahimovic and Jesse Lingard put them two ahead, before Southampton brought it back to 2 each thanks to a Manolo Gabbiadini double.But a late header by Ibrahimovic gave United victory for their first major trophy under Jose Mourinho.In the Premier League Tottenham defeated Stoke 4-0 to move up to second in the table.last_img read more

Lakers’ DeMarcus Cousins has harassment charges dropped, case dismissed

first_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREUCLA alum Kenny Clark signs four-year contract extension with PackersThe Lakers did not release an official statement about the case. Coach Frank Vogel acknowledged that the case had been “present in my mind” but declined to comment on a legal matter of a player.Cousins is expected to miss the season after tearing his ACL during an August workout. He has not spoken publicly to the media since the injury.Still, the former All-Star has been very much a part of the team’s fabric through the early part of the season, attending practices and sitting courtside at games as he rehabilitates his injury. Vogel said the Lakers had “internal discussions” about Cousins’ inclusion that he declined to disclose, but said he feels in general that allowing injured players to participate in team activities helps with the mental challenge of recovery.“All of our injured players we want to be as involved as possible,” Vogel said.Related Articles Newsroom GuidelinesNews TipsContact UsReport an Error Trail Blazers beat Grizzlies in play-in, earn first-round series with the Lakers Lakers practice early hoping to answer all questions How athletes protesting the national anthem has evolved over 17 years center_img Trail Blazers, Grizzlies advance to NBA play-in game; Suns, Spurs see playoff dreams dashed Lakers center DeMarcus Cousins is no longer facing legal issues in his home state of Alabama, after third-degree harassment charges were dropped and a misdemeanor case was dismissed.Two people with knowledge of the situation confirmed to Southern California News Group that the case had been dismissed. Moshae Donald, Cousins’ attorney who initially told ESPN that the case had been dismissed, did not immediately respond to an SCNG inquiry.The case arose in August, when Cousins’ ex-girlfriend Christy West alleged that Cousins had threatened to shoot her during an argument regarding their son. TMZ released an audio recording of a man, who West said was Cousins, threatening, “I’m gonna make sure I put a bullet through your (expletive) head.”Cousins, 29, could still be subject to potential discipline from the NBA as part of the league’s domestic violence policy. An NBA spokesman told SCNG: “We are reviewing the outcome of today’s proceedings.” Lakers, Clippers schedules set for first round of NBA playoffs last_img read more

Police arrest man who walked over 300 miles to have sex with a 14-year-old

first_imgThe Winnebago County Sheriff’s department is reporting that they have arrested a 32-year-old man who reportedly walked over 300 miles to meet and have sex with an internet user he believed was a 14-year-old girl.The incident occurred in early October.Officials say Tommy Lee Jenkins was communicating with a Winnebago County Sheriff’s deputy who told Jenkins that they were a 14-year-old girl named “Kylee” who lived in Neenah, Wisconsin with her mother.  At some point during their communications which were all of a sexual nature, Jenkins asked if the “teen” would like him to come to Neenah to have sex.   After the “teen” agreed, Jenkins began walking from Whitestown, Indiana to Wisconsin, which is 351 miles away.Jenkins took several selfies during his journey and sent them to the teen as he made his way to her town. Once he arrived, he was arrested.“Our nation faces an epidemic of child sexual abuse, with the Internet making it too easy for predators to communicate with children across the country,” United States Attorney Matthew D. Krueger said in a statement. “The Justice Department is committed to working with federal, state, and local law enforcement agencies to prosecute child sexual abuse aggressively.” Jenkins has since charged with using a computer in an attempt to persuade, induce or entice a minor to engage in unlawful sexual activity. If convicted, he faces up to 10 years behind bars. He is scheduled to appear in federal court on October 23th.last_img read more


first_imgARCADIA, Calif. (March 30, 2016)–Ensconced for decades in Santa Anita’s luxurious Chandelier Room, a vintage Steinway Grand Piano has been donated by Santa Anita to the Arcadia Performing Arts Foundation, located on the campus of Arcadia High School.“We are extremely excited about this extraordinary donation to the Arcadia Performing Arts Foundation by Santa Anita Park,” said Gary Kovacic, Arcadia Mayor and President/CEO of the Arcadia Performing Arts Foundation. “This piece of Arcadia history will find a loving home at the Arcadia Performing Arts Center, and it will continue to provide musical magic to Arcadia students, residents and theatre patrons for generations to come.”Arcadia Unified School District Superintendent David Vannasdall was equally appreciative.“I know our students will absolutely love playing this beautiful Steinway Grand Piano,” said Vannasdall. “It’s such a great opportunity that we can now offer our students for years to come, thanks to Santa Anita.”Manufactured in 1908, this magnificent instrument provided melodic background music to generations of race-goers that included legendary Hollywood figures such as Clark Gable, Betty Davis, the Marx Brothers, John Wayne, Fred Astaire, Judy Garland, Marlene Dietrich and many others.“We are delighted to be able to donate this beautiful instrument to such a worthy cause as the Arcadia Performing Arts Center,” said Pete Siberell, Santa Anita’s Director of Community Services and Special Projects. “To think of all the many thousands of people this piano has helped to entertain, it’s only fitting that it remain close by, here in Arcadia.”Santa Anita’s Chandelier Room, which was part of a recent $35 million renovation, remains a popular race day destination for weekend race goers and offers an ambiance befitting Santa Anita’s standing in the racing world.last_img read more